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Is TruAge the best Biological Age test? TruDiagnostic review

Is TruAge the best Biological Age test? TruDiagnostic review

You’ve certainly heard about your biological age, which is how your body is ageing in comparison to the average rather than just how many years you have lived in it, if you’re wondering whether your healthy (or terrible!) lifestyle is having an impact (called your chronological age). Read this TruDiagnostic review to discover more.

There are various methods for determining your biological age, each with advantages and disadvantages, but one of the most popular and accurate is to examine how your DNA structure changes with age, which is known as epigenetic age.

What is epigenetic age

Aging is associated with two major types of factors. On the one hand, we separate intrinsic factors, such as our genetic proclivity to follow a specific “ageing pathway” for the degeneration of our skin’s tissues, structures, and molecules.

On the other side, there is a whole slew of external factors that have been dubbed the exposome. These elements have a significant impact on ageing trends. Exposure to the sun, exposure to aggressive agents, nutrition, physical inactivity, pollution, and even smoking are all examples. They are referred to as “epigenetic factors.”

What is the importance of epigenetics on aging?

Epigenetics is defined as the set of extrinsic stimuli that influence DNA activity without altering its sequence. To use a musical metaphor, genetics is the score and epigenetics is the interpretation: the score is the foundation, but the end result is mainly controlled by how it is interpreted.

This reversible mechanism allows your body to control which bits of your DNA are read without altering the DNA itself. This is known as ‘Epigenetics,’ and it is how your body changes gene expression throughout your life.

Thus, our lifestyle has a significant impact on the activation of these epigenetic alterations, which can then activate or deactivate specific regions of our genetic code. Taking care of this can help to prevent the onset of aging-related disorders.

 

Who is TruDiagnostic? TruDiagnostic review

TruDiagnostic was established in 2020 and has already made strides in the longevity sector with the goal of enhancing people’s lives. Through knowledge gained from the fluid epigenome, TruDiagnostic hopes to empower patients and doctors to make the best decisions possible at the appropriate moments.

Because it can be cross-trained to other biomarkers in a multi-omic framework, the company’s fundamental view is that methylation is a biomarker with significant promise. With a sector now dominated by doctors practicing integrative, cash-pay care, TruDiagnostic has a clear road to profitability and urgent plans to start selling kits and insights directly to consumers in 2023 . 

Through their TruAge test, TruDiagnostic now focuses mostly on age-related diagnoses, but as more data is gathered for various health sectors, this will grow.

TruDiagnostic offers lab services to research institutes in addition to the clinical test options. This covers services for RNA-Sequencing, genomic processing, and proteomic analysis. It features a strong bioinformatics division that can examine huge databases for fresh health prediction techniques. TruDiagnostic’s main objective is to become a leader in its clinical service, and although it continues to develop the strongest ageing algorithms to date, it is also advancing into other fields of epigenetic interpretation.

What make TruDiagnostic  different

Utilizing the advantages of its substantial cash pay provider database is what sets TruDiagnostic apart from the competition. In this field, doctors, nurses, and other healthcare professionals have a special interest in preventive medicine and ageing. In addition to enabling the organisation to use them for testing distribution, this also makes it easier to collect the distinctive and in-depth variables that come from direct-to-consumer testing.

Since methylation data is useless without the outcomes and phenotypes of patients, these variables are crucial, especially as the science of methylation continues to develop. TruDiagnostic is able to perform low-cost clinical trials and collect health history and data, including blood chemistries, immunological profiles, microbiome testing, and more, thanks to its partnerships with doctors. This information enables research into the relationships between these symptoms and the methylome, which in turn makes TruDiagnostic uniquely qualified to develop new algorithms that provide even greater value.

As the cohort ages, TruDiagnostic will update its special rate of ageing algorithm every five years to enable even more precise rate of ageing determinations. To make saliva collection a practical and reliable option, it also wants to develop saliva conversion algorithms for all published ageing clocks.

The company also intends to make a skin ageing algorithm available; this will be the first epigenetic system to calculate skin ageing using phenotypic measurements. They predict that medical spas and skincare companies will both heavily utilise this technology in the future. Last but not least, TruDiagnostic intends to make a special research array available to study the imprintome. Together with partners, TruDiagnostic has for the first time determined all regions of the genome that are imprinted and passed down from one patient.

These areas have a strong connection to many diseases and will be available as a variety of research studies for private research groups and universities studying autism, Alzheimer’s, schizophrenia, and a variety of other imprintome-related diseases.

What is TruAge

TruDiagnostic review

TruDiagnostic review Tru Diagnostic TruAge Complete Collection

TruAge is a collection of reports about epigenetic age. Methylation is the epigenetic marker that TruDiagnostic examines. It is now the most practical and reliable method of determining the biological effects of ageing.

Due to variations in cell type and stresses, different parts of our body age at different rates. TruDiagnostic  came to the conclusion that there is no one, ideal approach to assess ageing because those various ageing rates also have distinct effects on health and lifespan. There are far too many important things the scientists can teach you about ageing and how it affects your health to be summed up in a single “Biological Age” figure.

In order to replace a single statistic with a set of reports, TruDiagnostic expanded TruAge.

TruDiagnostic provides a more comprehensive view of your changing health and lifespan by examining many aspects of epigenetic ageing, as well as trait reports and other sophisticated metrics.

Test your biological age & improve your health Now

Use our exclusive TruDiagnostic discount code BESTBWELL for 12% off ($59.88 discount)

Why TruAge is the best longevity test

  • In comparison to Telomere Length or Proteomics alone, DNA Methylation has the strongest potential to predict health outcomes and lifetime. It is trusted as an objective assessment of ageing by research institutions around the country and employed in over 21 clinical trials in 2023 .
  • TruDiagnostic runs out of their private, CLIA-certified laboratory, thus turnaround time is 2 to 3 weeks once they get your sample.
  • The world’s largest private epigenetic database
  • Private research is ongoing to produce new ageing algorithms and identify new Trait Reports – your previous TruAge reports will grow with time.
  • Transparency: All lifestyle recommendations are based on published reports, and your raw epigenetic data is available for independent verification.
  • No third-party data sharing – HIPAA compliant
  • Your participation in their collaborative research is voluntary, with consent forms for individual studies made accessible as they become available.

Who can get TruAge Biological Age Test 

TruDiagnostic provides comprehensive epigenetic age testing services that are already used by academic research organisations and clinical trials across the United States ,UK and Canada. They signed a new distribution partnership with HealthyLongevity.global, a distributor specialising in longevity based in the Czech Republic.

For small firms, HealthyLongevity.global offers logistical support, local regulatory guidance, and centralised sample shipment. TruDiagnostic is able to focus on their speciality – epigenetic research and testing – while yet reaching out to a larger worldwide audience.

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Use our exclusive TruDiagnostic discount code BESTBWELL for 12% off ($59.88 discount)

 

How to use epigenetics to stay healthy

It is above all a question of preventing the appearance of serious diseases, degeneration, and cancerous tumors, these diseases being more frequent with age.

Our lifestyle can be modified to express the “good” genes (like tumor suppressor genes), and inhibit the expression of the “bad” ones like those for inflammation, certain cancers or autoimmune diseases, etc.

Aging, even for a person without a degenerative disease, is characterized by a more or less rapid decrease in certain functionalities . At the biochemical level, aging is characterized by a lower efficiency of mitochondria, a shortening of telomeres (a kind of “caps” at the end of chromosomes), a “rust” of the cell (because of free radicals) favoring the oxidation and inflammation, a weakening of the hormonal and immune system, an increased imbalance of the intestinal microbiota…

The biologist Yann Olivaux speaks on this subject of “epimicrobiotics”, that is to say food and water parameters likely to influence intestinal bacteria. All these processes are regulated by a kind of internal biological clock and epigenetics makes it possible, to a certain extent, to delay their appearance. How ? By :

  • A balanced, hypocaloric and hypotoxic diet,
  • Regular and moderate exercise, good breathing,
  • Quality of sleep,
  • Non-exposure to pollutants (by inhalation, contact or ingestion),
  • Elimination of xenobiotics (drugs, smoking, endocrine disruptors, etc.),
  • The management of stress and emotional shocks,
  • A good social and family environment,
  • Positive emotions.

Without detailing each theme, it is known that a poor lifestyle (alcohol, tobacco, stress, ultra-processed diet, sedentary lifestyle, etc.) can generate changes likely to trigger cancer. Smoking leads to changes in the expression of certain genes, in particular those involved in the control of cell division (hundreds of chemicals are present in the products of combustion and nicotine is an endocrine disruptor), which transforms healthy bronchial cells to cancerous cells. Drugs are also capable of modifying genes (cocaine, morphine, amphetamines, etc.).

Conversely, the establishment of a healthy lifestyle ensures that these genes favorable to cancerization are not expressed (or little). The American Academy of Sciences reports that, in several men with prostate cancer, significant changes in their lifestyle and in their diet favorably modified the expression of genes involved in carcinogenesis. This was verified on prostate biopsies performed before the start of life changes, then three months later.

 

Foods that favorably influence epigenetics

Food is important: in addition to providing the necessary energy and the “bricks” of our body, it provides molecules necessary for DNA methylation, for example vitamin B9.

These include fruits, raw vegetables, green vegetables, legumes, broccoli, yeast… Nuts and seeds are rich in methionine, an “essential” amino acid involved in methylation. Spinach, beetroot, quinoa are rich in betaine. Soy has an epigenetic action on DNA linked to tumor transformation. Plants qualified as “adaptogens” (ginseng, eleutherococcus, rhodiola, ashwaganda, maca, astragalus, cordyceps, etc.), spices such as basil, caraway, cardamom, cinnamon, turmeric, garlic, saffron, and a few others , by allowing us to adapt to stressful situations, provide “epinutrients”.

Moreover, “the regular practice of fasting under medical supervision … induces spectacular epigenetic effects”. Research has also proven that fasting can have a positive effect on a large number of diseases (epigenetic changes have been observed after 2 days of fasting).

If the diet is deficient, which is common with age, it is recommended to supplement with omega 3 fatty acids, selenium, zinc, vitamins of group B, C, E and especially D (much more than a vitamin) capable of regulating certain genes, either directly or in association with other molecules. Resveratrol and its derivatives (polyphenols) activate the P53 gene.

An astragaloside present in astragalus root is known to have a delayed effect on senescence, by inhibiting a tumor suppressor protein, a “switch” which in turn activates genes. To improve the methylation reactions which decrease with aging, some authors recommend supplementation with “epinutrients”, in particular amino acids such as methionine, S-adenosyl-methionine or betaine. Beware, however, of excessive methylation that can generate too much homocysteine, a marker of cardiovascular risk. Everything is in measure.

Foods with bad epigenetic influence

Certain foods taken in excess lead to epigenetic modifications that generate diseases: excess of salted meats, fried foods, preserves, simple sugars, animal fats, alcohol, so-called “ultra-processed” foods, especially if they are little masticated.

Lifestyle, stress and epigenetics

Moderate exercise, restful sleep, a social environment, a good state of mind, are important assets to turn on the right genetic switches. Moderate exercise performed twice a week can alter the expression of 7000 genes in fat cells.

To manage stress, prevent “burn out”, an activity such as yoga, stretching, relaxation, meditation, positive thoughts, are essential. Eastern medicines, which do not separate body and mind, such as Ayurveda, consider food toxins to be as important as mental toxins.

Other disciplines can have powerful effects on the body: autogenic training, hypnosis, sophrology and others. Even licking (for animals) or petting (for humans) has the power to influence genes. Spiritual teachers also know that our body is programmable by words and thought. In medicine too, by the placebo effect. Therapies such as EFT, EMDR, mindfulness meditation (MBSR), go in the same direction. Changing our thoughts alters the biochemistry of the body. The process is reversible.

Conversely, negative thoughts, continuous fear, stress, emotional isolation, are perceived by our brain as a threat and it engrams “switches” which will also turn genes on or off. This is the “nocebo” effect, that of “toxic beliefs”. Nutritionist Marion Kaplan recalls the importance of the “diagnostic conflict” which can aggravate cancer or multiple sclerosis. When a medical diagnosis falls abruptly, activating stress reactions, there is little room left for the body’s self-repairing solutions.

The biochemist Joël de Rosnay insists on the importance of our daily behavior on the regulation of our genes: “our way of living, working and loving, the taste for living, the pleasure in what we do, the quality of the social network, of our family relationships… epigenetics allowing us to better control the speed of aging, and to succeed in “aging young” rather than living old”.

Cellular and epigenetic regeneration

Finally, remember that our body is constantly regenerating. It occurs in each of our cells, one hundred thousand biochemical reactions per second. Our liver and our skin regenerate in 1 month and a half, our bones in a few months. Our entire body rebuilds itself in less than 2 years. We are therefore endowed with self-healing capacities that we are beginning to understand scientifically thanks to epigenetics. Some drugs could finally see the light of day by acting on stem cells. But medical research is currently in animal experiments, revealing new perspectives for treating diseases. For humans, an ethical epigenetics, an “epigen-ethics” (see: epigenome.eu) is emerging.

Stay healthy longer

Dr. Astrid Stuckelberger, a Swiss physician, targets the prevalence of epigenetic processes with advancing age. This amounts – through the adoption of an appropriate lifestyle – to slowing down degenerative processes (“aging without age” according to her) by detoxifying, “deoxidizing”, “de-inflaming”, leading to an increase in life expectancy without diseases. degenerative (life expectancy in good health). Oscar Wilde’s quote (taken up by Kennedy, Malraux and others): “one should not seek to add years to one’s life but rather try to add life to one’s years” joins in this sense epigenetics .

Getting older without showing age-related symptoms is what epigenetics teaches us, showing us how to regain control of our health, of our genes. And for that, let’s make good resolutions and try to keep them, by adopting a way of life that will allow us to stay in shape as long as possible, us… and the children to come.

In an interview on CNews, commenting on his penultimate book “The genius in your genes”, Dawson Church confirms this point of view based on several hundred scientific publications: “We can activate or deactivate our genes with our thoughts and our emotions… you can greatly increase your potential with epigenetics”.

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